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Publications

Regan, C., Preall, J. (August 2022) Practical Considerations for Single-Cell Genomics. Curr Protoc, 2 (8). e498. ISSN 2691-1299

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Amor, C., Fernández-Maestre, I., Chowdhury, S., Ho, Y., Nadella, S., Graham, C., Carrasco, S. E., Nnuji-John, E., Feucht, J., Hinterleitner, C., Barthet, V.J.A., Boyer, J.A., Mezzadra, R., Wereski, M.G., Tuveson, D.A., Levine, R.L., Jones, L.W., Sadelain, M., Lowe, S.W. (January 2024) Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction. Nature Aging. 

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Tonelli, C., Yordanov, G.N., Hao, Y., Deschênes, A., Hinds, J., Belleau, P., Klingbeil, O., Brosnan, E., Doshi, A., Park, Y., Hruban, R.H., Vakoc, C.R., Dobin, A., Preall, J., Tuveson, D.A. (January 2024) A mucus production programme promotes classical pancreatic ductal adenocarcinoma. Gut. ISSN 0017-5749

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Benitz, S., Steep, A., Nasser, M,, Preall, J., Mahajan, U.M., McQuithey, H., Loveless, I., Davis, E.T., Wen, H., Long, D.W., Metzler, T., Zwernik, S., Louw, M., Rempinski, D., Salas-Escabillas, D., Brender, S., Song, L., Huang, L., Zhang, Z., Steele, N., Regel, I., Bednar, F., Crawford, H.C. (December 2023) ROR2 regulates cellular plasticity in pancreatic neoplasia and adenocarcinoma. bioRxiv. 

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Yao, M., Preall, J., Yeh, J., Pappin, D.J., Cifani, P., Zhao, Y., Shen, S., Moresco, P., He, B., Patel, H., Habowski, A.N., King, D.A., Raphael, K.L., Rishi, A., Sejpal, D.V., Weiss, M., Tuveson, D., Fearon, D.T. (September 2023) Plasma cells in human pancreatic ductal adenocarcinoma secrete antibodies to self-antigens. JCI Insight. e172449. ISSN 2379-3708 

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Sroka, M.W., Skopelitis, D., Vermunt, M.W., Preall, J.B., El Demerdash, O., de Almeida, L.M.N., Chang, K., Utama, R., Gryder, B., Caligiuri, G., Ren, D., Nalbant, B., Milazzo, J.P., Tuveson, D.A., Dobin, A., Hiebert, S.W., Stengel, K.R., Mantovani, R., Khan, J., Kohli, R.M., Shi, J., Blobel, G.A., Vakoc, C.R. (September 2023) Myo-differentiation reporter screen reveals NF-Y as an activator of PAX3-FOXO1 in rhabdomyosarcoma. Proceedings of the National Academy of Sciences of USA, 120 (36). e2303859120. ISSN 0027-8424

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Kleeman, S.O., Thakir, T.M., Demestichas, B., Mourikis, N., Loiero, D., Ferrer, M., Bankier, S., Riazat-Kesh, Y.J.R.A., Lee, H., Chantzichristos, D., Regan, C., Preall, J., Sinha, S., Rosin, N., Yipp, B., de Almeida, L.G.N., Biernaskie, J., Dufour, A., Tober-Lau, P., Ruusalepp, A., Bjorkegren, J.L.M., Ralser, M., Kurth, F., Demichev, V., Heywood, T., Gao, Q., Johannsson, G., Koelzer, V.H., Walker, B.R., Meyer, H.V., Janowitz, T. (August 2023) Cystatin C is glucocorticoid responsive, directs recruitment of Trem2+ macrophages, and predicts failure of cancer immunotherapy. Cell Genomics, 3 (8). p. 100347. ISSN 2666-979X

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Delgado, A. P., Nemajerova, A., Rao, M., Li, J., Marchenko, N., Preall, J., Moll, U. M., Egeblad, M., Powers, S. (May 2022) Single-cell genomic analysis of triple-negative breast cancer fibroblasts uncovers evolutionarily conserved features and potential therapeutic targets. bioRxiv. https://doi.org/10.1101/2022.05.05.490693

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Wu, X. S., He, X., Ipsaro, J. J., Huang, Y., Preall, J. B., Ng, D., Shue, Y. T., Sage, J., Egeblad, M., Joshua-Tor, L., Vakoc, C. R. (May 2022) OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage. Nature. ISSN 0028-0836

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Gegenhuber, B., Wu, M.V., Bronstein, R., Tollkuhn, J. (May 2022) Gene regulation by gonadal hormone receptors underlies brain sex differences. Nature. ISSN 0028-0836

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Bhatia, S., Kramer, M., Russo, S., Naik, P., Arun, G., Brophy, K., Andrews, P. A., Fan, C., Perou, C. M., Preall, J., Ha, T., Plenker, D., Tuveson, D. A., Rishi, A., Wilkinson, J. E., McCombie, W. R., Kostroff, K., Spector, D. L. (April 2022) Patient-derived triple negative breast cancer organoids provide robust model systems that recapitulate tumor intrinsic characteristics. Cancer Res, 82 (7). pp. 1174–1192. ISSN 1538-7445

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Lin, X., Gaudino, S. J., Jang, K. K., Bahadur, T., Singh, A., Banerjee, A., Beaupre, M., Chu, T., Wong, H. T., Kim, C. K., Kempen, C., Axelrad, J., Huang, H., Khalid, S., Shah, V., Eskiocak, O., Parks, O. B., Berisha, A., McAleer, J. P., Good, M., Hoshino, M., Blumberg, R., Bialkowska, A. B., Gaffen, S. L., Kolls, J. K., Yang, V. W., Beyaz, S., Cadwell, K., Kumar, P. (January 2022). IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment. Immunity, 55(2), 237–253.e8. ISSN 1074-7613

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Hanasoge Somasundara, A. V., Moss, M. A., Feigman, M. J., Chen, C., Cyrill, S. L., Ciccone, M. F., Trousdell, M. C., Vollbrecht, M., Li, S., Kendall, J., Beyaz, S., Wilkinson, J. E., Dos Santos, C. O. (December 2021) Parity-induced changes to mammary epithelial cells control NKT cell expansion and mammary oncogenesis. Cell Reports, 37 (10). p. 110099. ISSN 2211-1247

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Henry, S., Trousdell, M. C., Cyrill, S. L., Zhao, Y., Feigman, M. J., Bouhuis, J. M., Aylard, D. A., Siepel, A., Dos Santos, C. O. (May 2021) Characterization of Gene Expression Signatures for the Identification of Cellular Heterogeneity in the Developing Mammary Gland. Journal of Mammary Gland Biology and Neoplasia. ISSN 1083-3021

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Steele, N. G., Biffi, G., Kemp, S. B., Zhang, Y., Drouillard, D., Syu, L., Hao, Y., Oni, T. E., Brosnan, E., Elyada, E., Doshi, A., Hansma, C., Espinoza, C., Abbas, A., The, S., Irizarry-Negron, V., Halbrook, C. J., Franks, N. E., Hoffman, M. T., Brown, K., Carpenter, E. S., Nwosu, Z. C., Johnson, C., Lima, F., Anderson, M. A., Park, Y., Crawford, H. C., Lyssiotis, C. A., Frankel, T. L., Rao, A., Bednar, F., Dlugosz, A. A., Preall, J. B., Tuveson, D. A., Allen, B. L., Pasca di Magliano, M. (April 2021) Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer. Clinical Cancer Research, 27 (7). pp. 2023-2037. ISSN 1078-0432

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Xu, X., Crow, M., Rice, B. R., Li, F., Harris, B., Liu, L., Demesa-Arevalo, E., Lu, Z., Wang, L., Fox, N., Wang, X., Drenkow, J., Luo, A., Char, S. N., Yang, B., Sylvester, A. W., Gingeras, T. R., Schmitz, R. J., Ware, D., Lipka, A. E., Gillis, J., Jackson, D. (December 2020) Single-cell RNA sequencing of developing maize ears facilitates functional analysis and trait candidate gene discovery. Dev Cell, S1534- (20). pp. 31021-31022. ISSN 1534-5807

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Somerville, T. D. D., Xu, Y., Wu, X. S., Maia-Silva, D., Hur, S. K., de Almeida, L. M. N., Preall, J. B., Koo, P. K., Vakoc, C. R. (May 2020) ZBED2 is an antagonist of interferon regulatory factor 1 and modifies cell identity in pancreatic cancer. Proc Natl Acad Sci U S A, 117 (21). pp. 11471-11482. ISSN 0027-8424 (Print)0027-8424

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Somerville, T. D. D., Biffi, G., DaBler-Plenker, J., Hur, S.K., He, X.-Y., Vance, K.E., Miyabayashi, K., Xu, Y., Maia-Silva, D., Klingbeil, O., Demerdash, O. E., Preall, J. B., Hollingsworth, M. A., Egeblad, M., Tuveson, D. A., Vakoc, C. R. (April 2020) Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation. Elife, 9. e53381. ISSN 2050-084x (Public Dataset)

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Chen, X., Sun, Y. C., Zhan, H., Kebschull, J. M., Fischer, S., Matho, K., Huang, Z. J., Gillis, J., Zador, A. M. (October 2019) High-Throughput Mapping of Long-Range Neuronal Projection Using In Situ Sequencing. Cell, 179 (3). 772-786.e19. ISSN 0092-8674 (Public Dataset)

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Carter, J. A., Preall, J. B., Atwal, G. S. (October 2019) Bayesian Inference of Allelic Inclusion Rates in the Human T Cell Receptor Repertoire. Cell Syst, 9 (5). pp. 475-482. ISSN 2405-4712 (Public Dataset)

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Carter, J. A., Preall, J. B., Grigaityte, K., Goldfless, S. J., Jeffery, E., Briggs, A. W., Vigneault, F., Atwal, G. S. (July 2019) Single T Cell Sequencing Demonstrates the Functional Role alpha beta TCR Pairing in Cell Lineage and Antigen Specificity. Frontiers in Immunology, 10. Article Number:1516. ISSN 1664-3224

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Elyada, E., Bolisetty, M., Laise, P., Flynn, W. F., Courtois, E. T., Burkhart, R. A., Teinor, J. A., Belleau, P., Biffi, G., Lucito, M. S., Sivajothi, S., Armstrong, T. D., Engle, D. D., Yu, K. H., Hao, Y., Wolfgang, C. L., Park, Y., Preall, J., Jaffee, E. M., Califano, A., Robson, P., Tuveson, D. A. (June 2019) Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts. Cancer Discov, 9 (8). pp. 1102-1123. ISSN 2159-8274

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Biffi, G., Oni, T. E., Spielman, B., Hao, Y., Elyada, E., Park, Y., Preall, J., Tuveson, D. A. (October 2018) IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma. Cancer Discov, 9 (2). pp. 282-301. ISSN 2159-8274

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